Neurotransmitter switching: New neuroplasticity in health and disease

Regulation of cell plasticity by insulin/IGF signaling: New insights from zebrafish

Oxytocin and the neural circuitry of social relationships: implications for autism

Microglia negatively regulate neuronal activity- An action beyond immune response

Transgenic approaches to reveal physiological roles of central vasopressin and oxytocin system

Islet homeostasis and transmembrane signaling

Human interstitial fluid circulatory network

Historical studies on Interstitial fluid flow

Final frontier: the interstitial Space-Experiments in Graz/Austria

Researches on extracellular matrix pathway

Effects of 3 week physical therapy on hemodynamic and endothelial responses in patients with Lymphedema

Mapping interstitial conduits for fluid transport and cell migration

Discussion

Roles of hemodynamic forces on endothelial function and dysfunction

Yin Yang 1 Phosphorylation at serine 118 induces vascular endothelial proliferation to promote atherosclerosis under flow

Stable flow-induced expression of KLK10 inhibits endothelial inflammation and atherosclerosis

Disturbed flow induces inflammation and atherosclerosis via activating the endothelial APEX1

Coupling of integrin α5 to annexin A2 by flow drives endothelial activation

Opening Ceremony Playback

AI-powered computational cardiology

Q & A

Introducing PHYSIOME modelling and the advantages of the PHYSIOME Journal for analyzing complex physiological networks

PHYSIOME modelling of skeletal muscle in investigating a Chinese herbal muscle relaxant

Unravelling the mechanism of a Chinese herbal Medicine using computational prediction

Sasang constitutional medicine and physiotype

Q & A

Chinese Culture Show

Calcium sensing and claudin regulation in kidney

Claudins in renal calcium physiology

The role of renal claudins in calciuria: focusing on metabolic acidosis

The role of renal calcium channels in kidney stone formation

Intravital calcium imaging in the kidney

Q & A

Super-resolution imaging of the fusion pore dynamics in chromaffin cells

Vesicle docking: SNARE-proteins interacting with a single vesicle revealed by atomic force microscopy

Negative regulation of exocytosis by amisyn/STXBP6

Fusion pore constriction in pituitary and gliocrine cells

Q & A

Vagal tone, brain perfusion and cognitive function in later life

How glia talks to neurones

Regulation of breathing by hindbrain Phox2b neurons

Role of glia in control of respiratory networks

Control of breathing by leptin singling in brainstem

Q & A

Lipophilic compounds from tree resin open voltage-gated potassium channels

PIP2 is a necessary cofactor for IKs channel gating

Structural basis for the modulation of human KCNQ4 by retigabine and linopirdine

Lipid interactions of crowded membrane proteins revealed by molecular simulations: ion channels and related membrane proteins

Regulation of ion channels by voltage-sensing phosphatase in sperm flagellum

Q & A

Molecular targets of environmental

Epigenetic regulation of energy homeostasis and its connection to healthy offspring.

Role of hypothalamic neuropeptides on the onset of puberty.

Over-nutrition alters the microRNA and transcriptional profiles in hypothalamic neurons thereby altering expression of feeding-related neuropeptides

Q & A

Bridging research and teaching——Illustrated with hypoxia experiments to explore a new model for the combination of research and teaching

"Virtual-real combination" video course for cell/molecular biology experimental teaching

Cooperation to solve pain points of teaching ：An example of the application of BAS behavioral software in Functional Experiment Course

Cognitive functions of the cerebellum

Q & A

Downregulated calmodulin expression contributes to the dysfunction of endothelial nitric oxide synthase and endothelial cell impairment in diabetes

Prohibitin2 maintains the contractile phenotype of vascular smooth muscle cells by counteracting hnRNPA1-mediated PKM alternative splicing and glucose metabolic reprogramming

RNA N6-methyladenosine modulates endothelial atherogenic responses to disturbed flow in mice

Pravastatin modulation of cholesterol in preeclamptic arteries alters vessel function linked to changes in caveolae form and distribution

Glutaminolysis governs glutathione content to maintain cardiac reserve

Biased activation of β2-AR/Gi/GRK2 signal pathway attenuated β1-AR sustained activation induced by β1-adrenergic receptor autoantibody

Q & A

IL-1β sensitizes mice to atrial fibrillation

Aging increases the susceptibility to ventricular arrhythmias through NOX4/ROS/CaMKII mediated calcium signalling

Mechanism of arrhythmia in mice with connexin43 dephosphorylation at serine 282

Prenatal disruption of the circadian clock increases left ventricular remodeling in male mice

Investigating the cardiotoxicity of the air pollutant, Phenanthrene, using a mouse model

High-resolution 3-D Volume Murine Heart Models for Topographic Characterization of Cardiomyocyte Subpopulations

Q & A

The world within – mechanisms and consequences of interactions of the gut with resident and invading microorganisms

Q & A

Neural networks for nociception and itch

Q & A

Alterations in kynurenine signaling in exercising older adults

Exercise-induced kynurenine pathway modulations and their effects on energy homeostasis

Kynurenine metabolism in patients with chronic obstructive pulmonary disease

Exercise-induced immune- and neuromodulation in humans with and without disease

Dysregulation of kynurenine metabolism in schizophrenia and multiple sclerosis

Q & A

Niche regulation of Intestinal stem cell function

Q & A

Early-life exercise enhances later-life resistance against LPS-induced sepsis through pipecolic acid-dependent mTORC1 inhibition

Aerobic exercise switch hippocampal microglias phenotype to relieve adolescent intermittent ethanol exposure in rats

Correlation between physical activity, Sleep Componants and Quality : in the context of type and intensity : a Cross-Sectional study among medical students

Identification of hub genes and therapeutic miRNAs in Duchenne muscular dystrophy based on an integrated bioinformatics strategy

Effects of hypochlorous acid and hydrogen peroxide on skeletal muscle function: implications for the pathophysiology of Duchenne muscular dystrophy

Omentin-1 reverses lung fibrosis by promoting lipogenic differentiation in myofibroblasts

Q & A

Imbalances of ACE/ACE2 and inflammatory cytokines in lung of hACE2 transgenic mice with SARS-CoV-2 infection

The tight junction protein ZO-1 directs mucosal repair by regulating mitotic spindle orientation

Molecular mechanism for the regulation of transport activity by the N-terminal cassette II of NBCn1

Latanoprost stimulates the basolateral ClC-K2 channel and Na⁺-Cl^- cotransporter in the distal convoluted tubule

Sleep architecture, periodic breathing and mood disturbance of expeditioners at Kunlun Station (4087m) in Antarctica

Perception about teaching and learning methodologies applied in physiology, a study on medical students of Pakistan

Q & A

Cellular signalling in the regulation of alveolar fluid homeostasis in the intact lung

Q & A

Placing neuropeptide signaling within glutamate/GABA contexts reveals its conspicuous role for sensorimotor circuit interaction

Contribution of neuropeptide-expressing neuronal cell types to spatial memory processes

Cortical vasoactive intestinal polypetide (VIP)-expressing Interneurons and the broadcasting of salience

The evolution of neuropeptide modulation: PACAP as a central regulator of endocrine and behavioral responses to stress

Q & A

The secret life of pericytes

Q & A

Transdermal GFR assessment in laboratory animals, overview and principles

A long-term users perspective on transdermal GFR assessment in mice

Renal self-maintaining macrophages contribute to salt and water balance through modulating sympathetic activities

Alginate oligosaccharide attenuates ischemia/reperfusion-induced acute kidney injury

How vertebrates regulate oxygen transport and consumption to survive oxygen lack

Q & A

α2δ-1 regulates synaptic NMDA receptors and sympathetic outflow in hypertension

Transcytosis within preautonomic capillaries – a single mechanism determining both hypertension-induced blood-brain barrier dysfunction and exercise-induced correction

Impaired Kv7 channel activity in amygdala contributes to elevated sympathetic outflow in hypertension

Site-specific gene targeting to restore cardiac sympatho-vagal balance during hypertension

Q & A

Hybrid hormones against obesity and type 2 diabetes: discovery, mechanism & clinical validation

Q & A

Construction of intelligent Five-in-One functional laboratory

Some thoughts on the construction of intelligent laboratories and digital teaching resources

Intelligent three in one functional experiment education platform and its curriculum system's construction and applications

An innovative training system for human physiology course through "Four-in-One" and "Industry-University Cooperation" strategies under the Four New Missions

Cardiac arrhythmia: beyond mice and rats

New trends in cardiac physiopathology from unconventional mammals model.

Fishing for insights in translational cardiac physiology

Unintended consequences: Fluid resuscitation worsens shock in an ovine model of endotoxemia

Effective rescue of acute myocardial ischemic injury by intravenous administration of chick early amniotic fluid

Q & A

Communication between intestinal sensory cells and gut neurons to carry messages about nutrients to the brain

Neuronal control of immune function

Neuronal sensing and control of nutrient metabolism

Nervous crosstalk to make antibodies

Q & A

Poster Discussion Playback

Poster Discussion Playback

Control of cortical network by astrocytes via a single molecule mGluR5

Astrocytic control of neuronal circuits and behaviors

Roles of astrocytes in synapse elimination

Dissecting astrocyte physiology with live super-resolution microscopy

Tripartite synaptic cleft proteome discoveries astrocyte-mediated inhibition in vivo

Q & A

Poster Discussion Playback

Poster Discussion Playback

The Journal of Physiology - a hub for the physiology community

The editorial process and advice on giving researchers the best chance of acceptance

Lessons learned as an Editorial Board Fellow for The Journal of Physiology

How The Journal of Physiology adds value to your research paper

Q & A

Lessons from yeast: autophagy as a cellular recycling system

Q & A

Sco-spondin point mutation induces corticosteroid hypersecretion in mice

Blockade of mineralocorticoid receptor ameliorates hypothalamic lipid mishandling and calcification in dexamethasone-exposed male wistar rats

PCSK9 involves in the high-fat diet-induced abnormal testicular function in male mice

Parietal cell-selective Slc26a9 deletion in mice leads to gastric immune dysregulation and diffused mucosal injury

Urolithin B improves pancreatic β-cells response to secretory demands: a look at IAPP aggregation, Ca2+-signaling modulation and insulin release

ACLY phosphorylation-mediated nuclear translocation promotes RNA transcription and early embryo development through enhancing histone acetylation

Q & A

The kisspeptin signalling pathway and its role in breast cancer biology

Intracellular intake mechanism of SPC, a causative molecule for vascular abnormal contraction

T lymphocyte-derived extracellular vesicles aggravate abdominal aortic aneurysm by promoting macrophage lipid peroxidation and migration via pyruvate kinase muscle isozyme 2

CD45.2+ urinary bladder mast cells may present a role within urinary contractile diseases

GSNOR acts as a negative regulator of plasma cell development and antibody production

An investigation of the angiogenic and inflammatory profiles in hypertensive disorders in pregnancy and possible biomarkers

Q & A

A motor theory of sleep control

Q & A

Forging causal links between neural circuit activity and behavior

Q & A

Cell specific regulation of TIMP4 in modulating inflammation in atherosclerosis and aortic aneurysms

Sex specific mechanisms of T cell mediated hypertension: how does estrogen loss contribute to postmenopausal cardiovascular disease

The gut microbiota in cardiovascular disease and hypertension

Antigen-presenting cells critically modulate inflammation in salt sensitive hypertension

Crosstalk between the adaptive and innate immune system in regulating cardiac wound healing

Q & A

Neural circuits underlying social memory and its dysfunction in neuropsychiatric disease

Q & A

Inhibition or genetic deletion of dopamine D3 receptors improve hippocampal synaptic plasticity and memory in adult and aged mice

Transcriptome alterations in ASMT knockout-induced depression-like behaviors and exercise effects

The PI3K/Akt pathway mediates the neuroprotective effect of progesterone Receptor against experimental traumatic brain injury: Histopathological study

Ero1α induces cognitive impairment through the endoplasmic reticulum stress pathway in hypoxia

Deciphering the mechanisms underlying cognitive impairment in autism spectrum disorders

Alcohol dependence activates ventral tegmental area-central amygdala circuitry in mice and rats

Q & A

Naringin prevents smokeless tobacco (SLT) induced mitochondrial health degradation, apoptosis in neurons, neurobehavioral pattern and improves systemic toxicity

Behavioral manifestations of neurotoxicity and systemic adverse effects of nano-calcium phosphates may be attenuated by antioxidant supplementation with Filipendula ulmaria extract in rats

Antinociceptive, anti-inflammatory and neuromodulatory effects of novel Iboga-derivatives in acute pain model in mice

Is motor cortical excitability responsible for chronic pain in fibromyalgia patients?

Psychological factors, genetic association and novel treatment option in Fibromyalgia

Characterisation of the divergent metabolic consequences of isocaloric high-sugar and high-fat diets in male Wistar rats using unsupervised PCA and supervised OPLS-DA

Q & A

Molecular and physiological insight of lipid droplet fusion and lipid storage

Q & A

Calcium waves in the heart: from flux balance to arrhythmias

From myocyte calcium waves to arrhythmias after myocardial infarction

Calcium in the liver: a taste for all seasons

RyR2 modulation and its consequences for systolic and dyastolic calcium release

Polycystin TRP channels are renal calcium signaling hubs

Q & A

Mitochondrial biology and human disease

Q & A

Information technology-enhanced instructional design in integrated physiology laboratory course

ESP refines physiology education

Paleophysiology: How fossil bone foramina can measure metabolic intensity of extinct vertebrates and brain perfusion of human ancestors

Q & A

Microbiota and skeletal muscle mass and function

Microbiota-gut-brain axis signalling in cardiorespiratory control

Role of the gut microbiome in vascular ageing

Microbial modulation of the intestinal neural circuits

Q & A

Maintaining balance under pressure: how concerted transporter regulation achieves fluid and salt homeostasis

Q & A

Pressure clamp methods to study mechanosensitivity channels

Introduction to Sutter Patch Clamp Systems

Sensing of phosphate and control of systemic phosphate homeostasis

Klotho modifies toxicity of phosphate

Phosphate and vascular inflammation

The role of pyrophosphate in ectopic calcification

Q & A

cAMP and cGMP compartmentation in cardiomyocytes

Interaction of the joining region in junctophilin-2 with the L-type Ca²⁺ channel is pivotal for cardiac dyad assembly and intracellular Ca²⁺ dynamics

Nanoscale regulation of signalling compartments in cardiomyocytes during heart failure

Caveolar mechano-electrochemical signal transduction in pathophysiology of atrial fibrillation during heart failure"

Q & A

Neural circuits mediating fear learning and extinction

Memory engram reactivation underlies impaired fear memory recall in Fragile X syndrome

Role of serotonergic modulation of circuit dynamics and plasticity on vestibular-related motor function

Losing balance: kainate receptors and brain disorders comorbidities

Q & A

Poster Discussion Playback

Poster Discussion Playback

Molecular Biology of the SARS-CoV-2 polymerase

The D614G mutation of the SARS-CoV2 and its role in the pandemic

Fighting SARS-CoV-2 with immunological wheapons

Unraveling the Devil's weaknesses: the potential of SARS-CoV-2 nucleocapsid protein as antiviral target

Biodiversity loss and the role of bats in the origin of the COVID-19 pandemic

Q & A

The gravity of exercise for a mission to Mars

Q & A

Poster Discussion Playback

Measuring energy expenditure in the field: insights from extraordinary animals

Physiological and behavioural plasticity of small mammals in a changing environment

Avoiding the bends: a new hypothesis that explains how stress may cause mass stranding of cetaceans

Hypometabolism in large arctic mammals

Life on a tight budget - Svalbard reindeers adaption to extreme seasonality

Q & A

Multimodal regulation of metabolism and aging by MG53

Q & A

Sex-dependent vasopressinerg influence on stress adaptation and stress-related psychopathologies

Sexually dimorphic alterations in hypothalamic peptides in mood disorders.

Estrogen receptor beta controls the hypothalamic-neurohypophysial system activity

Epigenetic mechanisms at the interface between sex steroids and sex chromosome genes in the sexual differentiation of the hypothalamus.

Density of GABAergic neurons in hypothalamic and limbic regions is modulated by testosterone levels

Q & A

How the innate immune system regulates repair of an injured tissue

Q & A

Poster Discussion Playback

PtdSer and membrane trafficking

PtdSer in MAMs and liver disease

Ptdser and SARS-CoV-2 Viral Entry

PtdSer in the regulation of ion transporters

Q & A

Integrated molecular response in muscle during and after exercise

Q & A

The unique characteristics and opportunities of assessment of online learning

Online flipped classroom: Students' online learning behavior and academic performance

Authentic online assessments: developing and assessing student problem solving skills

Creating online quizzes as robust assessments that discourage collusion between students

Capability-based assessment promotes the reform and development of online teaching in the post-COVID-19 era

Q & A

Regulation of intestine development and homeostasis by niche factors

Q & A

Poster Discussion Playback

KCNE1 is an auxiliary subunit of two distinct ion channel superfamilies

A novel ion conducting route besides the central pore in an inherited mutant of G-protein- gated inwardly rectifying K⁺ channel

Non canonical heteromerization of inwardly rectifying potassium channels

A tale of ‘Yin/Yang’: dynamic change of ion selectivity in TMEM16F

Q & A

Translating patient-specific physiome models of the respiratory system to clinical applications

Q & A

The role of Septins in vessel remodeling (EC and SMC)

The role of calpains in communication between platelets and the vascular wall.

The AMPK-ACE2 axis in vascular injury and repair

The effects of virus-encoded miRNA on vascular homeostasis in dilated cardiomyopathy

Q & A

Gas diffusion through membrane proteins

Q & A

Poster Discussion Playback

Development of the microbiota-gut-brain axis

Neuronal regulation of mucosal immune function

Fusobacterium and colorectal cancer

Microbiota dysbiosis and innate immunity in colorectal cancer

Q & A

Transcriptional regulation of Ca²⁺ signaling in cardiomyocytes of hibernating mammal

Ca²⁺ triggered arrhythmias, a seesaw game between SR Ca²⁺ release and uptake?

Novel molecular mechanism of RyR2 mutation associated CPVT

Junctophilin-2 in cardiac Ca²⁺ signaling and transcriptional regulation

Q & A

Poster Discussion Playback

Cerebrovascular mechanosensitivity and regulation of brain blood flow

Upregulation of TRPV4-mediated urothelial sensory transduction underlies bladder overactivity in a murine model of IC/BPS

Astrocyte endfoot mechanosensing of arteriole constriction via TRPV4 contributes to arteriole tone and vasomotion

Control of cerebral and systemic circulation by an intracranial baroreceptor

Q & A

Maternal factors and offspring and intergenerational health

Selenium, placental mitochondria and pregnancy and offspring outcomes

Maternal diet, exercise intervention and offspring cardio-metabolic disease risk

Therapeutic potential of Bifidobacterium in improving fetal metabolic outcomes

Maternal obesity programming of vascular dysfunction.

Q & A

Poster Discussion Playback

Baroreflex functionality in the eye of diffusion tensor imaging: clinical and therapeutic implications

Physiological rationale and pharmacological targets for sleep apnoea pharmacotherapy

Using bionics to reverse cardiovascular disease

Is high blood pressure self-protection for the brain?

Mechanism-guided development of an implantable hemotherapy

Q & A

Renal tubule transportome and kidney function

Renal sodium chloride cotransporter and hypertension

Physiological role of urea transporters in kidney

Viewing kidney tubule function through single nephron mass spectrometry

Q & A

Poster Discussion Playback

Contribution of both pre- and post-synaptic changes in the initiation and progression of sarcopenia

Mechanistic models to guide investigations into musculoskeletal ageing

(TBA) Interventions to prevent or delay motor neuron loss and NMJ disruption: effects on muscle atrophy and weakness

Transcriptomic analysis of skeletal muscle ageing and nerve crush: defining the role of denervation in sarcopenia

Targeting mitochondrial hydrogen peroxide to mitigate sarcopenia

Q & A

The 3 Rs and beyond: ensuring animal welfare and scientific value of research

Alternative methods for animal use in Brazil: state of the art

A successful alternative methods: using human iPS cells-derived cardiomyocytes and neurons

The way forward: Reaching goals with combined in vitro and in vivo studies/models

Q & A

Terminal control of dopamine signaling

Physiology and pathology of synaptic vesicle release

Improved norepinephrine sensors shine lights on in vivo noradrenergic activities

Catching synaptic vesicle dynamics: Time-resolved electron microscopy and functional correlation

Novel insights from direct small nerve terminal recordings

Q & A

Rescuing cerebral blood flow in small vessel disease of the brain

Q & A

Molecular basis for high-affinity agonist binding at the beta1-adrenoceptor

GPCR signaling bias through sub cellular location.

Apex and base-dependent GPCR signaling in cardiac tissues

Spying on neuromodulation by creating GPCR based fluorescent sensors

Molecular mechanisms of biased signaling at the angiotensin receptor

Q & A

Non-canonical role of dopamine receptor D2 in the modulation of neuroinflammation

Q & A

Closing Ceremony Playback

Role of mitochodnrial flashes in the regulation of bioenergetics in the heart

mitochondrial ATP and redox in heart disease development

SR-mitochondria communication in adult cardiomyocytes: A close relationship where the Ca2+ has a lot to say

The social communication of mitochondria and implications in cardiac physiology and pathology

Regulation of mitochondrial PTP in heart disease

Q & A

Identifying novel genes that control secretion during T cell killing

Q & A

Structure and function of the volume-regulated anion channel LRRC8

Structure and function of the calcium-activated chloride channel TMEM16A

Gating cycles of CLC proteins

Molecular physiology of CFTR gating

Ivacaftor potentiation of two cystic fibrosis mutations that affect the same residue in the twelfth transmembrane segment of CFTR

Q & A

Control of bradykinin signalling by cytosolic calcium: lessons from the pancreas

Targeting store-operated calcium channels to reduce the cytokine storm

Adapting calcium signatures in health and disease

SOC channels and host resistance to SARS-Cov-2

Tuning of calcium signaling and oxidative stress in pancreatic inflammatory control

Q & A

The global physiology education quiz network: engaging and enjoying physiology

Q & A

Toll-like receptor signaling and cardiovascular disease: roles beyond innate immunity

Modeling cardiac disease for better translation

Modulation of cardiovascular disease by diet

New targets in cardiac hypertrophy and heart failure

Molecular mechanisms underlying cardiac remodeling and dysfunction

Q & A

Hemoglobin levels mirror the topography of Switzerland: Evidence for an ancient but precise oxygen sensing process

Iron at high altitude and anemia

Epigenetics and high-altitude adaptation

Interaction of microbiota-metabolites-neuroendocrine network of male SD rats at a simulated altitude 5500m

John Cade's guinea pigs were hypothermic: lithium inhibits sympathetic brown adipose tissue nerve discharge and promotes heat loss

Q & A

Optogenetic control of enteric neuronal networks

Mechanisms underlying regulation of the gut mucosal homeostasis

Molecular and enteric neuronal substrates mediating estrogenic effects on colonic motility

Changes in the brain-gut axis in the development of gastroparesis in parkinson's disease

IAA alleviates DSS-induced colitis in mice

Q & A

Respiratory muscle action and rib-cage mechanics in childhood and adult neuromuscular disorders

Gene therapy for respiratory insufficiency in neuromuscular disorders

Therapeutic acute intermittent hypoxia to restore breathing (and non-respiratory function) with spinal injury and ALS

Therapeutic strategies for the prevention of respiratory abnormalities in pre-clinical models of Parkinson’s disease.

Accessory muscle support of breathing in dystrophin-deficient (mdx) mice

Q & A

Therapeutically targeting senescent cells to treat age-related diseases

The NAD⁺ -mitophagy axis in ageing and Alzheimer's disease and artificial intelligence based drug development

Subclinical myocardial aging: physiological and translational perspective on aging-related cardiovascular disease

Mitochondrial regulation of cardiac aging

Modeling aging and cardiovascular disease

Q & A

Caveolae/caveolins' role in ion channel physiology and in the onset of cardiac arrhythmias

Ankyrin-G mediates targeting of both Na⁺ and KATP channels to the cardiac intercalated disk

Novel therapeutic strategies for dystrophin-associated cardiomyopathies

Nano-scale deformation of cardiac t-tubules during stretch and contraction - structure and functional consequences

Q & A

The effect of omega-3 fatty acids on muscle mitochondrial metabolism

(TBA) The effects of omega-3 fatty acids on muscle protein metabolism

Omega-3 fatty acids and muscle mass and function in ageing

The efficacy of omega-3 fatty acids during inactvity

Q & A

Successful student engagement in remote and asynchronous courses

Development of an EPA (Entrustable Professional Activity)-based assessment to consolidate vertical integration of Physiology Lab. Experiences with Physical Examination

The use of digital story telling in physiology teaching